Source: http://moviesblog.mtv.com/2011/12/06/muppets-fox-news/
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Source: http://moviesblog.mtv.com/2011/12/06/muppets-fox-news/
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(Reuters) ? Slower tumor growth in kidney cancer patients taking Pfizer Inc's experimental drug, Inlyta, in a clinical trial was driven by a subset of patients who are rare in the United States, U.S. Food and Drug Administration researchers said.
In review documents released on Monday ahead of an expert advisory panel meeting on the drug, FDA staff expressed concern the Pfizer medicine appeared to work better in patients previously treated by cytokines that are rarely used in the United States, potentially limiting its appeal in the world's largest market.
U.S. kidney cancer patients are far more likely to be given Pfizer's Sutent as an initial treatment option rather than cytokines.
The FDA documents found the safety profile of Inlyta, clinically known as axitinib, to be similar to rival drugs. However, interim analysis of Pfizer's pivotal trial showed more overall deaths and more deaths related to treatment in patients who received Inlyta compared with those who took Nexavar, which is sold by Bayer AG and Onyx Pharmaceuticals Inc.
Inlyta, which inhibits certain receptors that can influence tumor growth and progression of cancer, is one of several new drugs Pfizer is banking on to help replace lost revenue from its top-selling cholesterol fighter, Lipitor, which began facing generic competition last week.
FDA staff said Pfizer's kidney cancer drug showed the same degree of liver enzyme elevation and potential for liver failure as some other drugs in its class, but had lower rates of skin related side effects and anemia than Nexavar.
About 61,000 Americans will be diagnosed with kidney cancer this year and one in five of them are expected to die from the disease, according to the American Cancer Society. Most often, this cancer occurs in people over 55 years old.
The drug is awaiting an approval decision in Europe for use in patients who failed to be helped by prior treatment.
In November 2010, Pfizer released results of a study showing axitinib significantly delayed the time before the disease progressed compared with Nexavar in previously treated patients with advanced kidney cancer.
The trial also found the Pfizer drug delayed progression of the disease by some 5.6 months in patients previously treated with cytokines, but only by 1.4 months in those initially treated with Sutent, known chemically as sunitinib.
A panel of FDA advisers will consider whether the discrepancy affects Inlyta's risk-benefit ratio.
The drug is also being tested in another late-stage trial for kidney cancer as both an initial treatment option and in previously treated patients. It is also being tested as a treatment for liver cancer.
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STILLWATER, Okla. ? Thousands of fans stormed the field and tore down goalposts after Oklahoma State's 44-10 victory over archrival Oklahoma, leaving at least 13 people injured, including two in critical condition, medical authorities said early Sunday.
Michael Authement, who heads the command post at emergency medical provider LifeNet EMS, told The Associated Press that a throng so big took to the field as the game ended that some fans were trampled and one person fell at least 15 feet onto concrete during a wild celebration by Oklahoma State fans.
No. 13 Oklahoma State routed the Sooners on Saturday night to win the Big 12 championship and make its case to play for the BCS national title. The Cowboys (11-1, 8-1 Big 12) snapped an eight-game losing streak in the rivalry and won their first outright conference title since 1948 in the three-team Missouri Valley.
"They won the game and stormed the field and ripped down the goalposts and some were jumping off the stands and hit the field and others got trampled. It was a nasty deal," Authement said.
He said the crowd was so big it took police at least 45 minutes to clear fans from the field at Boone Pickens Stadium in Stillwater. "There were thousands of people. Thousands of people stormed the field. You couldn't move there were so many people," he added.
AP photographs showed fans climbing atop the yellow goalposts and tearing them apart amid a crush of people on the field. Scores of hands stretched out to pull down the goalposts during the celebration.
Authement said nine ambulances, including six from LifeNet, rushed 11 of the injured away and the two in critical condition were flown to Oklahoma City hospitals. He said he knew of leg fractures but didn't have any details on the extent of the injuries, though two of the 13 had minor injuries and were treated at the scene and released.
Lesser injuries included broken ankles, ankle sprains and back sprains, said Shyla Eggers, public relations director for Stillwater Medical Center, adding eight injured came to her hospital. She told AP that her hospital received six of the injured in ambulances, two in private vehicles and at least two of the patients have been admitted and would undergo surgery on broken ankles.
"Our staff that was on hand took care of it. They were just very busy," Eggers said. "Game day is always busy."
She had no immediate details on the more serious injuries, saying two people were flown from the scene to hospitals in other cities in Oklahoma.
An Oklahoma State University police central dispatcher said she had no immediate details to release when contacted by AP and the public information officer did not immediately return messages seeking comment. Stillwater police and the Oklahoma highway patrol also had no immediate comment.
Authement said the fans began storming the field with about 20 seconds left in the game. He said he had reports of people falling and being trampled in the surge. "It lasted 45 minutes, I'm sure before they got the field cleared," he said.
He said he was handling game night duty when a magnitude-5.6 earthquake rocked central Oklahoma and the same stadium as fans departed minutes after Oklahoma State had beaten Kansas State. The Nov. 5 temblor, which could be felt as far away as Wisconsin, was the strongest in the state's history when it rattled players in the locker room and set the stadium press box rippling as the last of some 58,000 fans cleared out.
"This was way worse than the earthquake," Authement said.
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LJUBLJANA (Reuters) ? The centre-left mayor of Slovenia's capital Ljubljana was headed for victory in a parliamentary election on Sunday, early results showed, making the outgoing Social Democrats the latest casualties of the euro zone economic crisis.
The defeat for Prime Minister Borut Pahor was expected, but the victory for Ljubljana Mayor Zoran Jankovic, if confirmed, would mark an upset after weeks of opinion polls predicting a comfortable win for centre-right ex-prime minister Janez Jansa.
With nearly a third of votes counted, Jankovic's party was leading with 29.5 percent of the vote over Jansa's party with 25.9 percent and Pahor's party with less than 10.3 percent.
Jankovic will have to seek coalition partners, and Pahor said his party was ready to talk.
"We are open for dialogue," the outgoing prime minister told Pop Television. "We have to think of the future of this country."
An Alpine state of 2 million people, EU and euro zone member Slovenia was once a model of successful post-communist transition but is now facing renewed economic contraction, rising unemployment and the threat of a credit rating downgrade.
Pahor's government lost its majority in May amid internal policy squabbles and was ousted by parliament in September.
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PHILADELPHIA ? A Philadelphia-area teen says he was denied admission to the private boarding school supported by the Hershey chocolate company because he's HIV-positive.
A discrimination suit filed Wednesday claims the Milton Hershey School violated anti-discrimination laws in denying the 13-year-old's request for admission to the school for disadvantaged students.
The AIDS Law Project of Pennsylvania filed the lawsuit for the unidentified boy. Attorney Ronda Goldfein says her client requires no special accommodations.
In a statement released to WCAU-TV, school officials acknowledge the boy was denied admission for safety reasons. The school says it must protect the safety of the other 1,850 students already enrolled.
Founded in 1909 by chocolate maker Milton Hershey, the school educates low-income and socially disadvantaged students for free with the support of The Hershey Co.
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TEHRAN (Reuters) -Iranian diplomats expelled from Britain after radical youths stormed the British embassy in Tehran arrived home on Saturday to supporters bearing flowers and chanting "Death to England."
"Spy embassy closed for good," read one of the many placards carried by the crowd of some 100 men and women, most of whom appeared to be members of the hardline Basij militia, congregated at Imam Khomeini Airport.
Britain evacuated all diplomatic staff and closed its embassy in Tehran after it was stormed and ransacked on Tuesday. France, Germany, Italy and the Netherlands withdrew their ambassadors from Tehran in protest.
With swift condemnation from around the world, the embassy storming risks further isolating Iran which is already under several rounds of sanctions over the nuclear program that many countries fear is aimed at developing atomic bombs, a charge Tehran denies.
President Mahmoud Ahmadinejad has yet to comment on the incident, an indication, some analysts say, that it was organized by rival hardliners within the faction-riven establishment.
Iran's Foreign Ministry has expressed regret over the embassy invasion, which it said was a spontaneous overflowing of anger during a student protest. Britain says there must have been at least tacit approval by the ruling establishment.
Speaking to reporters at the airport, Foreign Ministry spokesman Ramin Mehmanparast warned Britain's European Union partners not to allow the diplomatic row to worsen their own ties with the Islamic Republic.
"The British government is trying to extend to other European countries the problem between the two of us, but of course we have told European countries not to subject their ties with us with the kind of problems that existed between Iran and Britain," he was quoted as saying by the Fars news agency.
(Writing by Robin Pomeroy; Editing by Rosalind Russell)
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CAIRO (Reuters) ? Egyptian riot police and protesters observed a truce Thursday after violence that has killed 39 people in five days and the army said parliamentary elections would start on time next week.
Demonstrations by thousands of Egyptians furious at the slow transfer of power by military leadership to civilian rule have led to violent clashes with police, in scenes similar to the popular uprising that toppled leader Hosni Mubarak in February.
Protesters have vowed not to leave Cairo's central Tahrir Square, which once again has become the cradle of public protest in the most populous Arab country, until army rule ends.
The demonstrations appear to have polarized Egyptians, many of whom worry that unrest will prolong economic stagnation.
In new blows to confidence, the Egyptian pound weakened to more than 6 to the dollar for the first time since January 2005, and Standard & Poor's lowered its rating on Egypt.
The agency cut Egypt's long-term, foreign- and local-currency sovereign credit ratings to B+ from BB-, saying a "weak political and economic profile" had worsened further.
Egypt's ruling army council said it was doing all it could to prevent more violence. In a statement, it apologized, offered condolences and compensation to families of the dead, and promised a swift investigation into who was behind the unrest.
NO ELECTION DELAY
A ruling council member, General Mamdouh Shaheen, told a news conference the parliamentary vote, whose first stage is due to begin Monday, would go ahead on time. "We will not delay elections. This is the final word," he said.
Another council member, Major-General Mokhtar al-Mullah, took a swipe at the demonstrators. "If we look at those in Tahrir, regardless of their number, they do not represent the Egyptian people, but we must respect their opinion," he said.
Mullah said the army hoped to form a new government before Monday to replace Prime Minister Essam Sharaf's cabinet, which resigned during this week's violence without giving a reason.
Demonstrators in Tahrir said the truce had taken hold from midnight. Cranes hauled concrete barriers, later reinforced with barbed wire, across streets leading to the nearby Interior Ministry, flashpoint for much of the recent violence.
"Since about midnight or 1 a.m. there were no more clashes. We are standing here to ensure no one goes inside the cordon," said Mohamed Mustafa, 50, among a group barring a street nearby.
They were guarding a barricade made of a broken metal fence, a telephone booth laid on its side and part of a lamp post.
At the other end of the street, littered with shattered glass, lumps of concrete and heaps of rubbish, at least two army armored personnel carriers blocked the route. Mustafa's group said police were on the front line, and behind them the army.
Lines of Tahrir protesters manned similar barriers to block access to Mohamed Mahmoud Street, scene of repeated fighting.
"We have created a space separating us from the police. We are standing here to make sure no one violates it," said Mahmoud Adly, 42, part of a human cordon four ranks deep.
The protests in Cairo and elsewhere pose the gravest challenge to Egypt's army rulers since they took over from Mubarak, overthrown on February 11 after an 18-day uprising.
The thousands who thronged Tahrir Square were undeterred in their determination to rid Egypt of army rule. "He goes, we won't," declared a banner referring to the army commander, Field Marshal Mohamed Hussein Tantawi.
The United States and European nations, alarmed at the violence of the past few days, have urged Egypt to proceed with what has been billed as its first free vote in decades.
LACK OF TRUST
The army and the Muslim Brotherhood, which expects to do well in the polls, say it must go ahead, but many protesters do not trust the military to oversee a clean vote. Some scorn the Brotherhood for its focus on gaining seats in parliament.
The military council originally promised to return to barracks within six months, but then set a timetable for elections and drawing up a new constitution that would have left it in power until late next year or early 2013.
Tantawi pledged this week to hold a presidential vote in June that could pave the way for a transfer to civilian rule, but the demonstrators, angered by army attempts to shield itself legally from future civilian control, are unconvinced.
"The military council must leave and hand power to civilians. They don't want to leave so that their corruption isn't exposed," said 23-year-old student Ahmed Essam.
Before the truce, protesters had fought running battles with security forces around the Interior Ministry. The bloody chaos there contrasted with normal life in streets nearby.
(Additional reporting by Edmund Blair, Tom Perry and Tamim Elyan; Writing by Alistair Lyon)
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SALZBURG, Austria?? Move over Mozart. Toes in Salzburg are tapping to a new beat as residents finally embrace the Hollywood musical that put them on the map nearly half a century ago.
Playing for the first time in this haughty town of opera lovers, "The Sound of Music," has been met with surprisingly positive reactions in what is commonly considered a last bulwark of resistance to the iconic show.
"A wonderful performance," enthused Johann Fink as he waited at the coat check at the end of a recent performance at the ornate Salzburg State Theater.
Such a reception in Salzburg is hardly a given despite the global popularity of the musical that was based on a true story and immortalized by the 1965 multiple Academy Award winning movie.
Fans around the world may know every word of every song performed by Julie Andrews as the governess of seven children who charms ? then weds ? their widowed father Baron von Trapp, before the singing family flees the Nazis.
But this city resonates to another sound of music ? the music of Mozart, Beethoven, Brahms.
And it has a different concept of culture.
While residents earn millions each year from the tourists who come for sing-along tours of sites featured in the film, they traditionally view the visitors with benign disdain ? and occasionally as pests.
Residents of the upscale Salzburg neighborhood where the von Trapp home is located tried ? and failed ? to block attempts to turn the edifice into a hotel, fearing tourists would tie up traffic and make a nuisance of themselves. A museum dedicated to the film is still looking for a home after more than 600 residents in another neighborhood signed a petition three years ago against it, telling the city council they feared that local streets would be jammed with tour buses.
Resistance persists even though the city would literally be poorer without the musical's magnet effect.
Peter Proetzner, who guides daily buses full of tourists on pilgrimages of the sites immortalized by the film, cites a poll showing the Sound of Music as the city's second biggest draw ? right after the dozens of classical music events that resonate through its cobblestoned alleys.
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See a selection of the 42.5 million people expected to drive, fly or take the train to their Thanksgiving gatherings, the largest number since the beginning of the recession.
"The Sound of Music is better known than Mozart worldwide," he asserts.
South Koreans learn the songs as part of their English lessons. Some foreigners think "Edelweiss" ? composed for the musical by Richard Rodgers and Oscar Hammerstein ? is Austria's national anthem. And Austrian tourism surveys show that three out of four American visitors to Salzburg come because of the musical.
Australian Dianne Cole says she knows "absolutely nothing" about Austria ? and will probably go home still ignorant of the country's cultural, scenic and culinary delights.
"This is why I came to Austria," she said recently, as her Sound of Music tour bus set out for its first stop ? Leopoldskron Lake (where Maria and the children capsized their boat). "The sole reason is to do this tour."
In contrast, most Salzburgers don't even know the musical. In a city that traditionally raps American culture as trashy, residents prefer to be associated with Mozart, Salzburg's favorite son, instead of a film many write off as Hollywood kitsch.
And then there is the troubling Nazi component of The Sound of Music ? a reminder, reinforced by the Swastika flag and storm troopers on stage, that not only Mozart, but Hitler, too, was Austrian.
Austria has long shed its self-fabricated myth that it was a victim of Nazi atrocities instead of one of its most fervent supporters. Restitution panels have returned homes and precious artworks. Millions of euros (dollars) have been doled out to Holocaust victims and their descendants, and schoolbooks now deal in depth with this nation's complicity in the crimes of the Nazi dictator, born just 50 kilometers (30 miles) north of Salzburg.
"I think that this is truly the right moment in time, when Austrians are actually ready to deal with their past," says Andreas Gergen, who directed the German-language production.
Still, anti-Semitic sentiment remains. A survey of 1,070 Austrians conducted earlier this year showed that 12 percent want their country "free of Jews." Backed by the country's neo-Nazi fringe, the country's rightist FPO party is the second-strongest in the country ? although it now exploits Islamophobia instead of anti-Jewish sentiment.
And the sight of Nazis on stage may remind some older audience members of uncomfortable historical facts. Over 99 percent of Austrians voted in favor of their country becoming part of the Third Reich in 1938; proportionally more Austrians than Germans were Nazi party members, and many of Hitler's closest henchmen were Austrians.
Like the Salzburg version, the first full Austrian showing in Vienna in 2005 featured actors dressed as Nazi storm troopers standing guard at exits and a theater box filled with mock Nazi dignitaries ? clearly too painful for some. Back then, some elderly audience members who last witnessed brown-shirted men wearing swastika arm bands as children were so troubled they hastily left the theater without watching the performance.
Six years later, reactions to the Nazi theme are mixed.
"Of course it's not so pleasant for us Salzburgers to be confronted with it," said Judith Herbst. But the smartly dressed woman in her mid 60s said that as far as she was concerned the role of Austria in Hitler's crimes was no longer debatable.
For others, though, the sight of men in forbidden Nazi garb entering the theater remains traumatic.
"It was horrible for a moment ? almost unbelievable," said theatergoer Fink. "Thank God this era is in the past!"
But there were no gasps of dismay regarding the rest of the show.
Some hummed its ear-candy melodies at the coat check after the performance.
"Kitsch? I was afraid that would be the case," said Helmi Popeter. "But once you see it, you realize that's not so."
___
George Jahn can be reached at http://twitter.com/georgejahn
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Source: http://www.msnbc.msn.com/id/45400066/ns/travel-destination_travel/
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There?s a definite end-of-year, holiday feel to today?s Fresh iPhone Apps. Thanksgiving is just around the corner, but after that, the run-up to the Holiday Season and the New Year begins. Celebrate in style with a classic Charlie Brown storybook narrated by Peter Robbins, or see what 2012 has in store from the brains at The Economist. When it comes to gaming, try some top-down arcade shooting action with Space Tripper, or take on the role of Barry Steakfries again in a special holiday-themed version of Age of Zombies.
Apple chose A Charlie Brown Christmas for its iPad App of the Week this week, and with Thanksgiving upon us, it?s not much of a leap to start getting into the Christmas spirit. The app is an interactive storybook that includes original dialogue from the 1965 movie original. It?s also narrated by Peter Robbins, the original voice of Charlie Brown.
But since it?s an interactive storybook, A Charlie Brown Christmas also includes features like the ability to decorate a Charlie Brown Christmas tree, play Schroeder?s piano, and hear words read aloud to help kids learn to read along with the book.
With 2011 winding down, The Economist magazine has put together a big feature forecasting the world of the next 12 months. The best of that content is now available in The World in 2012?s ?Editor?s Highlights? app, which features articles, videos, photos and more of things and people to watch in 2012.
The World in 2012 is The Economist?s predictions for the next year, and you can get a jump-start on figuring out what (and who) will be a big deal in the next year with Editor?s Highlights. With lots of information and content, it?s a nice iPad version of the larger publication The Economist puts together, and a solid way to decide if you want the print edition.
Also known as Astro Tripper, its PC counterpart, Space Tripper is a top-down arcade shooter that marries solid tilt controls with touchscreen controls, all while keeping things relatively simple. You man a craft and are tasked with destroying all the enemies that appear in a given arena before the timer runs out. Tilting makes your ship move while tapping one side of the screen reverses the direction you?re facing ? either left or right ? and the other switches between two weapons.
You?ll need quick reflexes and some on-the-fly strategy in order to notch top scores in the exceedingly difficult Space Tripper, but with Game Center support, your reward will be seeing how well you stack up against players all over the world. Space Tripper packs 14 levels to fight through, plus more game modes you can unlock as you go.
Halfbrick?s favorite wise-cracking protagonist, Barry Steakfries, took on legions of zombies while traveling through time in Age of Zombies, and now a year later the developer has released a brand new version of the game called Age of Zombies Anniversary. The new version is on sale for a limited time and keeps everything that made the original great ? namely, fast-paced twin-stick shooter action and a wry sense of humor ? while adding new features.
Age of Zombies Anniversary now includes Retina display support and is optimized for newer-generation iPhones and iPads. It also offers Game Center support for achievements and leaderboards, as well as an additional story chapter set in the Wild West.
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Please post all "Players Wanted" threads in the Roleplayers Wanted forum!
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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.So for the pairings, each guy is going to pick the top two girls he'd like his chachter with. One of them will be his mate, the other will be his true love. So even if some is picked twice, they dont have to fight over her. (fun as that may be.) One person will have them as their mate, the other will have her as their true love. I pick the mate/true love part.
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