Friday, November 23, 2012

Elsevier Launches Leukemia Research Open Access Journal

Elsevier has launched a new open access, online journal, Leukemia Research Reports. It will publish ?a range of peer-reviewed short form papers, including brief communications, case reports, letters to the editors, images and debate articles about basic and/or applied clinical research in leukemias, lymphomas, multiple myeloma and other hematologic malignancies.?

The editors of Leukemia Research Reports are: Dr Suneel Mundle (Janssen Services LLC and Rush Medical College, Chicago, IL) and Dr Meir Wetzler (State University of New York at Buffalo School of Medicine and Roswell Park Cancer Center, Buffalo, NY).

The editors encourage the submission of articles relevant to normal and leukemic hemopoiesis, biochemistry, cell biology, immunology and molecular biology as well as epidemiologic and clinical studies. Coverage will encompass the application of oncogenes, genomics (gene expression profiles, microRNAs), proteomics growth factors, cell markers, cell cycle and differentiation agents, novel therapeutics and clinical trials in both the acute and chronic leukemias as well as the myelodysplastic syndromes.

In addition articles are solicited on the rapidly growing specialty of marrow or stem cell reconstitution after high dose therapy with curative attempt in patients with a wide range of neoplasms.

Source: http://www.science20.com/news_articles/elsevier_launches_leukemia_research_open_access_journal-96962

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Thursday, November 22, 2012

5 Reasons Why Groupon Is Struggling | Personal Finance ...

When Groupon (NASDAQ:GRPN) went public in November 2011, Investing Daily?s Jim Fink labeled it the worst Internet IPO of the year.

Just over 12 months later, it?s hard to argue with that call. Groupon has plummeted 88% from its IPO price of $20. Even Facebook (NASDAQ:FB), after its botched IPO, looks good compared to Groupon, with a fall of ?only? 40% since its initial offering back in May.
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Bad News Keeps on Coming for Groupon Investors
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Groupon?s latest stumble?a one-day 30% plunge to an all-time low of $2.76?came on November 9, after the company released yet another disappointing earnings report.
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In the third quarter, Groupon?s revenue rose 32% from a year ago, to $568.6 million. The company lost $3.0 million, or nil per share, compared to a loss of $54.2 million, or $0.18 a share, a year ago. Both figures missed the Street?s expectation of $0.04 a share in profits on revenue of $590 million.
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Groupon CEO Andrew Mason pointed ?continued challenges in Europe? as the main reason for the disappointing results. But that?s an oversimplification of the problems at Groupon. More worrying is the fact that its revenue growth has continued to slow as the daily deal craze fizzles.
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?In the fourth quarter of 2011, in its first earnings report as a public company, Groupon said its revenue nearly tripled,? writes the San Jose Mercury News. ?That fell to 89 percent in the first quarter of this year, 45 percent in the second quarter and 32 percent in the third.?
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What?s more, Groupon has never turned a profit, either prior to its IPO (see page 7 of its SEC registration statement) or after.
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Five Key Reasons Why Groupon Is Struggling
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Here are five other reasons why the daily deal site has fallen so hard in the past year. They also provide a good illustration of things to keep in mind when you?re deciding whether to add any new stock to your portfolio:

  1. Groupon faces stiff competition: At the end of the second quarter, Groupon controlled 53% of the daily deals market in the US, down from 56% in the previous quarter, according to data from industry research firm Yipit.
The company?s biggest competitor is privately held LivingSocial, with a 22% share, followed by Amazon Local at 20%. However, it also faces a growing number of small, locally based competitors in its main markets. As well, Google (NASDAQ:GOOG) has also entered the daily deals space with Google Offers. The move came after Groupon rebuffed the search giant?s effort to buy the company for $6 billion prior to the IPO.

You have to think they?re regretting that decision: Groupon?s market cap?the value of all its outstanding shares?is now just above $2 billion.

  1. Groupon?s business model is easily duplicated: The reason for the heightened competition? Groupon?s business model?of sending out daily emails offering recipients deals on a wide range of products or services?is easily copied.
As a result, the company is scrambling to move beyond daily deals. To that end, it launched Groupon Goods, an e-commerce site that sells a wide range of products. This business accounted for almost all of the company?s revenue growth in the latest quarter.
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However, selling products directly gives Groupon lower profit margins than the daily deals business, under which it simply connects vendors with customers and takes a cut of the sale. The company also faces massive competition in this space, including Amazon.com (NASDAQ:AMZN).
  1. Groupon?s customers are frustrated: The appeal of the daily deal coupons is clearly wearing off for the consumer. That?s partly because the discounts often come with strings attached that make them less convenient than they seem.
Even worse for Groupon, the retailers it relies on to provide the deals are souring on the strategy. A recent Raymond James survey found that 39% of merchants who had tried Groupon promotions were unlikely to do so again in the next couple years. Reasons included overly steep commission rates and the fact that one-off deals are a lousy way to encourage repeat customers. The study also showed that 32% of the businesses had lost money on the promotion.
  1. Groupon has a long record of accounting issues: The company has run afoul of the SEC on numerous occasions, including having to restate its 2011 fourth quarter earnings, as Jim Fink writes in ?Groupon?s Cooked Books: Beware IPOs With Shady Histories?:
?On March 30,?Groupon announced?that it would need to restate its fourth-quarter financial results because of a ?material weakness in its internal controls.? Specifically, its?initial reporting of fourth-quarter results?back on February 8 overstated revenue by $14.3 million, operating income by $30.0 million, net profit by $22.6 million, and earnings per share by $0.04.?
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That?s just one of the problems the company has had with overstated results. Others included two orders from the SEC to refile its registration statement in the run-up to the IPO. In the first instance, in August 2011, Groupon understated its operating losses by $120 million. The second time, the SEC ordered the company to lower its 2010 revenues by $400 million to reflect only net revenues and not revenues paid out to vendors.
  1. Groupon has a turnover problem: The company has now gone through three COOs in two years. In addition, in August it was revealed that Groupon?s head of national sales, Lee Brown?who had only been with the company since December 2010?was leaving. The news came shortly after the departure of Jayna Cooke, one of the company?s leading salespeople.
Bottom line: A company with even one of these problems represents a huge risk to your investments. One with all five should be avoided at all costs.
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This article by Chad Fraser was originally published on Investing Daily.
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Below, find more great content from Investing Daily:

A New Way to Play Australia?s High-Yielding Mid-Caps

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Stick With Dividend Stocks

Twitter: @investingdaily

No positions in stocks mentioned.

Source: http://www.minyanville.com/trading-and-investing/personal-finance/articles/groupon-grpn-facebook-fb-ipo-groupon/11/21/2012/id/46036

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Take a balanced approach to the next four years | The Business Times

Article date: Nov 20 2012

Marcus Straub

Marcus Straub

The election has come and gone. President Barack Obama has been re-elected and, as a nation, we face challenging decisions in reducing the deficit while still investing in our shared future. For the leadership of any company, the basic principles that allow all companies to thrive remain the same.

Austerity measures will be put in place to reduce government spending and bring down the deficit. As a result, some businesses could experience a decline in existing revenue streams and will need to adjust course to stay viable. Other businesses, however, will experience higher revenues due to increased government spending in specific areas as we invest in our future.

Overall, the business environment likely will become more challenging due to a decreased availability of funds in both the public and private sectors. It?s important to remember, however, we still have an economy. While it might not be the strongest one we?ve ever enjoyed, it?s not the weakest either. Customers will continue to buy what they need and want from businesses that deliver the greatest value.

Over the course of the next four years, the importance of producing high-quality products and services, delivering exceptional customer service and building empowered teams in a progressive and supportive work environment will ? as they always have ? remain at the heart of business success. Business owners and their management teams that focus on these fundamentals will experience even more success in our recovering economy.

Cutting costs will only take a business so far in weathering the coming challenges. While there?s no doubt becoming increasingly financially efficient is wise in both strong and weak economic environments, cutting expenses alone won?t position a business for success.

Companies also must invest in their people, improve product development, enhance customer service, create strategic marketing initiatives and deepen their market penetration. Businesses that choose to become as fiscally responsible as possible while at the same time strategically targeting their investments in future prosperity will not only survive, but thrive.

A powerful example of how to lower costs while investing in the future would be to hire new talent through the implementation of a job benchmarking platform. Every year vast amounts of capital leak out of businesses as a result of high turnover, lack of engagement and low productivity within their work forces. The statistically accurate job benchmarking process positions companies to hire top talent ? those individuals best suited to perform a given job at the highest level possible. When this is accomplished, precious resources are saved and retention improved. Productivity rises, and the future of the organization becomes brighter.

Another example would be to provide targeted training to all team members ? including owners, senior leaders and managers ? to close gaps among their behaviors, business acumen and identified skill sets. Delivering powerful trainings in these areas will position all team members to produce higher quality products and services and provide the exceptional customer service patrons must receive to keep doing business with their favorite companies.

Without a doubt, there wouldn?t be jobs if it weren?t for business owners. But there wouldn?t be production of goods and services if it weren?t for the team members who create and deliver them. And without customers to buy goods and services, there would be no businesses at all. Business owners, their team members and the customers they both serve are all intricately connected. The stronger a company?s team, the more satisfied customers will be. This is what allows businesses to become increasingly profitable.

Business leaders who control what they can ? the smooth, efficient and effective operations of their operations ? and don?t allow themselves to become distracted by political comings and goings will position their companies, teams, communities and country for increased happiness and success.

In the end, all businesses have the potential to contribute in profound ways to the continued greatness and prosperity of this nation. When business leaders put their people, customers and the quality of what they offer first, they create situations that allow everyone to win.

Related Articles:

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  4. Adding relationship value in the internet age
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  6. Are you paying attention to the loyalty factor?

Source: http://thebusinesstimes.com/take-a-balanced-approach-to-the-next-four-years/

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Home . Improvement . Interior . Design . and . Decorating . Article ...

20 November, 2012 (00:47) | Decorating House Ideas | By: Specs Detail

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How A Person Can Refinish The Maple Staircases?Individuals who are planning to develop a home would rather possess maple staircases, simply simply because they can simply match up any kind of concept you have. In situation you make a plan of the property as well as you might like something which can last for a lengthy period, this might be the actual best answer for a person personally. Building a stairs is amongst the most intricate components in creating a home. To make sure that it stays powerful as well as practical, you require to understand keeping it. Refinishing the maple staircases is a certain way to keep it, and a person may employ individuals to do the job, you may as well complete the entire stairways by yourself.?Innovative Methods to Utilize Walls Artwork?If you want to provide a space a change, walls artwork is an excellent place to begin. Utilize these types of ideas to include gorgeous walls artwork within your area these days.

?Modify the actual Infant?s Space Along With Setting Walls Graphics?Designing your child?s space is really a pleasant adventure. A Person can create a gorgeous, tranquil atmosphere with regard to children to develop as well as perform by using setting walls graphics.?What Exactly Is a Minimal House??Minimal houses in numerous instances are regarded as appealing but instead dull as well as difficult areas to reside easily in. However the benefit of minimal residing is not really really in not including comfort as well as ease however in taking on a relaxed, much easier atmosphere.?Taking On Minimalism in Your House?There tend to be several crucial good points about making a minimal house for example attaining a more appealing as well as more calm residing atmosphere. However can a person really change a regular house right in to a minimal one??Should Have Style Inspirations?Many individuals truly like to spruce their own environment plan stuff that tend to be awesome, on-the actual-inexpensive as well as uncomplicated. Allow your creation go outrageous and additionally have fun using these excellent diy tasks!?2012?s Crucial Home Design Styles?Along With increasingly more people choosing to attach our own present abodes as well as get the actual best from our own environment instead of ?turning? as well as starting ourself in to the pending housing industry, very good of do it yourself as well as restoration continues to be healthful in 2012. However do you understand the crucial styles that people really should be purchasing for??


Related posts:

  1. Pears, Apples and Interior Decorating Ideas
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  3. 12 Interior Decorating Ideas To Steal From Paris Fashion Week ? Glamour (blog)
  4. Interior Decorating Tricks And Tips To Decorate Your Home
  5. Corals Images, Modern Home Decorations and Interior Design Ideas

Source: http://houseremodelingins.specsdetail.com/home-improvement-interior-design-and-decorating-article-category/

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Source: http://lawrence53.typepad.com/blog/2012/11/home-improvement-interior-design-and-decorating-article.html

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Getting your Home ready for Winter: Preventative Roof Maintenance ...

With winter fast approaching, now is the best time to ensure your roof will survive the impeding winter weather. And the best way to do this is with a little preventative roof maintenance and timely repairs.

Preventative Roof Maintenance

  1. Pre-Winter Roof Inspection: First and foremost, scour your roof (both interior and exterior roof components) for any warning signs of damage, including dark spots, obvious water damage from roof leaks, missing or broken shingles, clogged or broken gutters, damaged flashing, and more.
  2. Check your Attic Insulation: According to EnergyStar?, properly insulating your attic can help slash your heating and cooling costs by as much as 20%.
  3. Repair Roof Damage: Repairing roof damage now will prevent it from worsening during the winter.
  4. Trim Trees: Trim any trees and branches that may be hanging over your roof. This will cut down on some of the debris that finds its way on, and eventually damages, your roof.
  5. Periodic Roof Inspections: It is important to periodically inspect your roof to look for damage, especially immediately following a winter storm.

Allied Remodeling: Your Baltimore Roofer!

If you would rather leave the hard work to the professionals, that is okay with us! Just give Allied Remodeling a call today. Our roofing experts will be able to examine your roof, analyze your specific problem, and provide you with your best options moving forward.

If you have any questions, you can reach Allied Remodeling by calling 410-769-9700 or?by clicking here today!

Allied Remodeling: ?Your friend in the business!?

Check us out on?Facebook and?Twitter as well!

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Tags: Allied Remodeling, attic insulation, Baltimore Roofer, preventative roof maintenance, Repair Roof Damage, roof inspection, roofing experts

Source: http://alliedremodeling.com/blog/home-improvement-tips/getting-your-home-ready-for-winter-preventative-roof-maintenance-repair/

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Kitchen Contractors Beverly Hills - CA Home Contractors

Remodeling your kitchen in Beverly Hills doesn?t need to expensive. Whether you wish to assemble & install your kitchen cabinets yourself, or have us do all the work, CA Kitchen Remodeling Beverly Hills enables you to definitely change your kitchen with beautiful all-wood cabinets for less money. That?s lower than the home improvement stores. You can expect a large collection of kitchen cabinet sizes, styles, colors and accessories. We want to assist you to develop a kitchen of beauty and efficiency.

We make finding a qualified, expert Kitchen remodeling specialists easy! Let us help you with any project. Our experts in Beverly Hills can design, renovate, and add a Kitchen for your home! CA Kitchen Remodeling makes remodeling projects simple! Simply request a totally free estimate and build your kitchen you?ve always dreamed of!

Remodeling your home kitchen is usually a great remedy to update the inside look of your property to make your kitchen area an improved match for the lifestyle and needs. As there are numerous actions to some kitchen?s remodeling undertaking that can become difficult, it is important that you make detailed decisions before starting. In terms of home kitchen remodeling, cautious and detailed preparing needs to be absolutely essential.

We will enable you to sort through the endless possibilities of layouts, styles, lighting, fixtures, accessories and even more ? transforming your kitchen into a masterpiece that you just along with your household will cherish for a lifetime. A kitchen renovation is actually a complex job that?s hinged on many distinct variables, involving anything from workspace preparing and color scheme option to time and cost considerations.

There are several key elements to be considered before beginning to remodel a Kitchen, including proper planning, budgeting, and execution with the whole process. Beverly Hills Kitchen remodeling can be as simple as painting walls and replacing a faucet, or it may involve tougher tasks for example removing the walls and installing new and improved facilities say for example a heated floor.

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Source: http://cahomecontractors.com/Blog/2012/11/20/kitchen-contractors-beverly-hills-2/

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